神经退行性病

    Repurposing verapamil for prevention of cognitive decline in sporadic Alzheimer’s disease
  • Figure 1|A mechanistic analogy of how verapamil works to preserve cognition.

    Although, the exact molecular mechanisms leading to such effect are not entirely understood, they are likely a result of not one but, a combination of favorable actions (Figure 1). Verapamil primarily functions to regulate Ca2+ and maintain homeostasis. This is essential since Ca2+ imbalance is known to be a critical factor in the pathogenesis of many neurodegenerative conditions and most notably AD. This Ca2+ imbalance leads to mitochondrial dysfunction, increases production of reactive oxygen species, impairs synaptic plasticity and mediates apoptosis. Verapamil also possesses acute anti-inflammatory activity, partly due to its early-stage downregulation of TXNIP and associated inhibition of the NLRP3 inflammasome pathway (Ahmed et al., 2021).


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  • 发布日期: 2021-12-08  浏览: 518
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