神经退行性病

    Impact of alpha-synuclein pathology on adult neurogenesis: evidence for multilayered mechanisms
  • Figure 1|Developmental processes of adult neurogenesis in the subgranular zone (SGZ) of the hippocampus (Hipp). 

    Stage-specific morphological features, as well as signaling mechanisms that drive the process of adult neurogenesis and neuronal differentiation have been characterized (Figure 1). The time-dependent manner of changes in NPC morphology is accompanied by genetically distinguished stages in which expression of specific mRNA and protein markers can be observed (Gon?alves et al., 2016). To comprehend the proportion of adult neurogenesis and therefore its importance, it is estimated that in the adult rodent brains several thousand new neurons are born every day. Since the original studies from Altman and Das (Abdissa et al., 2020), it was shown that adult neurogenesis processes are involved in maintaining brain tissue homeostasis and play a major role in both health and disease. 


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  • 发布日期: 2022-01-12  浏览: 411
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