中国神经再生研究(英文版) ›› 2019, Vol. 14 ›› Issue (7): 1202-1207.doi: 10.4103/1673-5374.251299

• 综述:神经损伤修复保护与再生 • 上一篇    下一篇

涉及意识障碍患者意识恢复的神经影像学特征

  

  • 出版日期:2019-07-15 发布日期:2019-07-15
  • 基金资助:

    韩国政府国家研究基金会(NRF)资助(MSIP)

Neuroimaging characterization of recovery of impaired consciousness in patients with disorders of consciousness

Sung Ho Jang, Young Hyeon Kwon   

  1. Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea
  • Online:2019-07-15 Published:2019-07-15
  • Contact: Young Hyeon Kwon, BS, kyh7648764@daum.net
  • Supported by:

    This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIP) (No. 2018R1A2B6000996; to SHJ).

摘要:

关于意识障碍患者关键大脑区域的研究可以在开发相关神经康复或神经介入治疗策略时提供有用信息。此次综述回顾了使用正电子发射断层扫描,脑电图/经颅磁刺激,弥散张量成像和弥散张量纤维束成像技术在意识障碍恢复过程中大脑变化研究中的应用。大部分研究报道了大脑幕上区域或结构在意识障碍恢复中的重要性。已确定的与意识障碍恢复相关的重要脑区或结构是:前额皮质、基底前脑、前扣带皮质和顶叶皮质,这些脑区或结构可以是意识障碍患者的神经康复或神经介入的目标区域。但大多数研究是病例报告,因此,有必要进一步开展涉及更多意识障碍患者的研究,从而获取与意识障碍恢复有关的的脑区或结构的更详细信息。

orcid: 0000-0002-4378-113X (Young Hyeon Kwon)

关键词: 意识, 植物人状态, 最低意识状态, 上行网状激活系统, 弥散张量成像, 神经影像, 神经再生, 综述

Abstract:

Elucidation of critical brain areas or structures that are responsible for recovery of impaired consciousness in patients with disorders of consciousness is important because it can provide information that is useful when developing therapeutic strategies for neurorehabilitation or neurointervention in patients with disorders of consciousness. In this review, studies that have demonstrated brain changes during recovery of impaired consciousness were reviewed. These studies used positron emission tomography, electroencephalography/transcranial magnetic stimulation, diffusion tensor tractography, and diffusion tensor tractography/electroencephalography. The majority of these studies reported on the importance of supratentorial areas or structures in the recovery of impaired consciousness. The important brain areas or structures that were identified were the prefrontal cortex, basal forebrain, anterior cingulate cortex, and parietal cortex. These results have a clinically important implication that these brain areas or structures can be target areas for neurorehabilitation or neurointervention in patients with disorders of consciousness. However, most of studies were case reports; therefore, further original studies involving larger numbers of patients with disorders of consciousness are warranted. In addition, more detailed information on the brain areas or structures that are relevant to the recovery of impaired consciousness is needed.

Key words: consciousness, vegetative state, minimally conscious state, ascending reticular activating system, diffusion tensor imaging, neuroimaging, neural regeneration, review