中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (2): 418-426.doi: 10.4103/1673-5374.317991

• 原著:周围神经损伤修复保护与再生 • 上一篇    下一篇

坐骨神经移位修复引起的大鼠脑功能重塑：多模静息态血氧水平依赖性功能磁共振分析

  

  • 出版日期:2022-02-15 发布日期:2021-10-08

Brain functional remodeling caused by sciatic nerve transposition repair in rats identified by multiple-model resting-state blood oxygenation level-dependent functional magnetic resonance imaging analysis

Yu-Song Yuan1, 2, 3, #, Hai-Lin Xu1, 3,  #, Zhong-Di Liu3, Yu-Hui Kou1, 2, 3, Bo Jin1, 2, 3, Pei-Xun Zhang1, 2, 3, *   

  1. 1Department of Trauma and Orthopedics, Peking University People’s Hospital, Peking University, Beijing, China; 2Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing, China; 3National Center for Trauma Medicine, Beijing, China
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Pei-Xun Zhang, PhD, zhangpeixun@bjmu.edu.cn.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, Nos. 31771322, 81671215 (to PXZ); the Beijing National Science Foundation, Nos. 7212121 (to PXZ); the National Key Research and Development Plan of China, No. 2018YFB1105504 (to PXZ); Shenzhen Science and Technology Plan Project, No. JCYJ20190806162205278 (to PXZ); Sanming Project, No. SZSM202011001 (to PXZ); the Fundamental Research Funds for the Central Universities, Clinical Medicine Plus X - Young Scholars Project of Peking University China, No. PKU2020LCXQ020 (to YHK); the Key Laboratory of Trauma and Neural Regeneration (Peking University), the Ministry of Education China, No. BMU2019XY007-01; and the Ministry of Education Innovation Program of China, No. IRT_16R01.

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摘要：

下肢神经移位修复是周围神经损伤重要的治疗方法之一，但这种手术对脑重塑的影响尚不明确。（1）实验建立了坐骨神经横断模型大鼠，将右侧坐骨神经远端通过神经导管连接左侧坐骨神经近端；（2）大鼠右后肢经电生理检测可见神经传导，且有髓神经结构明显恢复，胫骨前肌和腓肠肌的湿重有所恢复；（3）多模静息态血氧水平依赖性功能磁共振分析见大鼠多个脑区状态发生变化，建立了新的反射弧，产生了对靶器官运动和感觉功能控制的作用。表明坐骨神经移位修复可诱发脑功能重塑。实验于2015年12月9日经北京大学人民医院伦理委员会批准（批准号2015-50）。

https://orcid.org/0000-0001-7200-2281 (Pei-Xun Zhang)

关键词: 神经移位修复, 重塑, 大脑连通性, 磁共振成像, 周围神经损伤, 脑网络, 分数低频振荡振幅, 局部一致性数据

Abstract: Lower extremity nerve transposition repair has become an important treatment strategy for peripheral nerve injury; however, brain changes caused by this surgical procedure remain unclear. In this study, the distal stump of the right sciatic nerve in a rat model of sciatic nerve injury was connected to the proximal end of the left sciatic nerve using a chitin conduit. Neuroelectrophysiological test showed that the right lower limb displayed nerve conduction, and the structure of myelinated nerve fibers recovered greatly. Muscle wet weight of the anterior tibialis and gastrocnemius recovered as well. Multiple-model resting-state blood oxygenation level-dependent functional magnetic resonance imaging analysis revealed functional remodeling in multiple brain regions and the re-establishment of motor and sensory functions through a new reflex arc. These findings suggest that sciatic nerve transposition repair induces brain functional remodeling. The study was approved by the Ethics Committee of Peking University People’s Hospital on December 9, 2015 (approval No. 2015-50).

Key words: brain connectivity, brain network, fALFF, MRI, nerve transposition repair, peripheral nerve injury, ReHo, remodeling

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