中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (2): 409-417.doi: 10.4103/1673-5374.317992

• 原著:退行性病与再生 • 上一篇    下一篇

富氢水调节阿尔茨海默病模型小鼠神经炎症和肠道菌群减轻病理损伤 

  

  • 出版日期:2022-02-15 发布日期:2021-10-08

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer’s disease through reducing neuroinflammation and modulating intestinal microbiota

Yi-Tong Lin1, #, Qing-Qing Shi1, #, Lei Zhang1, #, Cai-Ping Yue1, Zhi-Jun He1, Xue-Xia Li1, Qian-Jun He2, Qiong Liu1, Xiu-Bo Du1, 3, *   

  1. 1College of Life Sciences and Oceanography, Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen University, Shenzhen, Guangdong Province, China; 2Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong Province, China; 3Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, China
  • Online:2022-02-15 Published:2021-10-08
  • Contact: Xiu-Bo Du, PhD, duxiubo@szu.edu.cn.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, No. 21771126 (to XBD); and the Shenzhen Bureau of Science, Technology and Information of China, No. JCYJ20180305124000597 (to XBD).

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摘要：

氢具有治疗阿尔茨海默病的潜力，但既往研究使用的是立体定向注射这一侵入性方法来给予活性氢，在实际临床应用上存在限制。实验设计给3×Tg-AD小鼠富氢水替代饮用水的方式进行干预，7个月后进行观察，富氢水能减少阿尔茨海默病模型小鼠突触损失和神经元死亡，并抑制海马中老年斑并降低Tau的过度磷酸化和神经原纤维缠结的产生，同时改善小鼠的大脑能量代谢障碍和肠道菌群平衡，调节小鼠脑内的炎症反应。初步显示了富氢水作为一种有效的氢供体，治疗阿尔茨海默病模型小鼠的作用。实验于2014年10月12日经深圳大学单位伦理委员会批准（批准号SYXK 2014-0140）。

https://orcid.org/0000-0003-4907-074X (Xiu-Bo Du)

关键词: 氢疗法, 阿尔茨海默病, 神经退行性疾病, 抗炎, β淀粉样蛋白, 神经原纤维缠结, 生物能, 肠道菌群

Abstract: Hydrogen exhibits the potential to treat Alzheimer’s disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer’s disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer’s disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer’s disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China (approval No. AEWC-20140615-002) on June 15, 2014.

Key words: Alzheimer’s disease, amyloid-β, anti-inflammation, bioenergetics, gut microbiota, hydrogen therapy, neurodegenerative disease, neurofibrillary tangles

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