中国神经再生研究(英文版)

中国神经再生研究(英文版) ›› 2022, Vol. 17 ›› Issue (6): 1318-1323.doi: 10.4103/1673-5374.327349

• 原著:脊髓损伤修复保护与再生 • 上一篇    下一篇

振荡电场刺激促进脊髓损伤后轴突再生及运动功能恢复

  

  • 出版日期:2022-06-15 发布日期:2021-12-17

Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury

Yi-Xin Wang1, 2, Jin-Zhu Bai1, 2, *, Zhen Lyu1, 2, Guang-Hao Zhang3, 4, Xiao-Lin Huo3, 4   

  1. 1Department of Spine and Spinal Cord Surgery, Beijing Bo’ai Hospital, Rehabilitation Research Center, Beijing, China; 2School of Rehabilitation Medicine, Capital Medical University, Beijing, China; 3Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, China; 4School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China
  • Online:2022-06-15 Published:2021-12-17
  • Contact: Jin-Zhu Bai, PhD, baijinzhu@126.com.
  • Supported by:
    This study was supported by the National Natural Science Foundation of China, No. 30801222 (to JZB).

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摘要：

振荡电场刺激是一种潜在的脊髓损伤修复方法，既往已有基础和临床研究将其应用于脊髓损伤治疗中，但其作用机制及神经修复作用与振荡电场刺激时程的相关性仍得以充分阐明。建立T10脊髓挫伤大鼠模型后，立即开始振荡电场刺激，持续12周。结果显示，神经功能的改善需要振荡电场持续刺激6周以上，才能有效促进脊髓损伤大鼠运动功能的恢复，且作用机制可能与振荡电场促进轴突再生、抑制星形胶质细胞增生、改善星形胶质细胞线性排列的作用相关。实验于2019年9月20日经中国康复研究中心研究伦理委员会批准（批准号2019017）。

https://orcid.org/0000-0003-2284-782X (Jin-Zhu Bai)

关键词: 振荡电场刺激, 脊髓损伤, 轴突再生, 星形胶质细胞, 增殖, 定向, 运动功能恢复, 刺激持续, 神经再生, 神经修复

Abstract: Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS. The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks. The underlying mechanism may be related to the effects of OFS on promoting axon regeneration, inhibiting astrocyte proliferation, and improving the linear arrangement of astrocytes. This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University (supplemental approval No. AEEI-2021-204) on July 26, 2021.

Key words: astrocyte orientation, astrocyte proliferation, axonal regeneration, locomotor recovery, neural regeneration, neural repair, oscillating field stimulation, spinal cord injury, stimulus duration

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