中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 18-22.doi: 10.4103/1673-5374.343882

• 综述:退行性病与再生 • 上一篇    下一篇

阿尔茨海默病中的细胞外囊泡:从病理学到治疗方法

  

  • 出版日期:2023-01-15 发布日期:2022-06-16

Extracellular vesicles in Alzheimer’s disease: from pathology to therapeutic approaches

Marta Garcia-Contreras, Avnesh S. Thakor*    

  1. Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, USA
  • Online:2023-01-15 Published:2022-06-16
  • Contact: Avnesh S. Thakor, MD, PhD, asthakor@stanford.edu.
  • Supported by:
    This work was supported by the Radiology Research Fund for Alzheimer’s Disease at Stanford University (to AST).

摘要: https://orcid.org/0000-0001-8014-7966 (Marta Garcia-Contreras); https://orcid.org/0000-0001-7395-0515 (Avnesh S. Thakor)

Abstract: Alzheimer’s disease is a progressive and fatal neurodegenerative disorder that starts many years before the onset of cognitive symptoms. Identifying novel biomarkers for Alzheimer’s disease has the potential for patient risk stratification, early diagnosis, and disease monitoring in response to therapy. A novel class of biomarkers is extracellular vesicles given their sensitivity and specificity to specific diseases. In addition, extracellular vesicles can be used as novel biological therapeutics given their ability to efficiently and functionally deliver therapeutic cargo. This is critical given the huge unmet need for novel treatment strategies for Alzheimer’s disease. This review summarizes and discusses the most recent findings in this field.

Key words: Alzheimer’s disease, brain, diagnostic, extracellular vesicles, isolation methods, microglia, neurodegenerative diseases, neuroinflammation, neurons, therapy