中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (1): 38-46.doi: 10.4103/1673-5374.343891

• 综述:退行性病与再生 • 上一篇    下一篇

脂肪组织、系统性炎症和神经退行性疾病

  

  • 出版日期:2023-01-15 发布日期:2022-06-16

Adipose tissue, systematic inflammation, and neurodegenerative diseases

Ana Paula de A. Boleti1, Pedro Henrique de O. Cardoso1, Breno Emanuel F. Frihling1, Patrícia Souza e Silva1, Luiz Filipe R.N. de Moraes1, Ludovico Migliolo1, 2, *   

  1. 1S-Inova Biotech, Programa de Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, MS, Brazil; 2Programa de Pós-Graduação em Biologia Celular e Molecular, Programa de Pós-Graduação em Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, Brazil
  • Online:2023-01-15 Published:2022-06-16
  • Contact: Ludovico Migliolo, Postdoc, ludovico@ucdb.br.
  • Supported by:
    This work was supported by the Brazilian funding agencies CNPq, and FUNDECT (to LM).

摘要: https://orcid.org/0000-0002-6606-2189 (Ludovico Migliolo)

Abstract: Obesity is associated with several diseases, including mental health. Adipose tissue is distributed around the internal organs, acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the tissues. Excessive nutritional intake results in hypertrophy and proliferation of adipocytes, leading to local hypoxia in adipose tissue and changes in these adipokine releases. This leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory cytokines. The presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling, which can generate a neuroinflammatory process. In this review, we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive dysfunction. We also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain, particularly the hypothalamus and hippocampus, and that this is partially responsible for these negative cognitive outcomes. In addition, we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.

Key words: adiposity, anti-obesity drugs, hypothalamic inflammation, metabolic disease, neurodegenerative disease, neuroinflammation