中国神经再生研究(英文版) ›› 2023, Vol. 18 ›› Issue (9): 1942-1943.doi: 10.4103/1673-5374.363830

• 观点:脑损伤修复保护与再生 • 上一篇    下一篇

咖啡因恢复早产新生儿脑室内出血模型中的神经元损伤和炎症反应

  

  • 出版日期:2023-09-15 发布日期:2023-03-06

Effect of caffeine in the intraventricular hemorrhage of the preterm newborn

Pilar Alves-Martinez, Monica Garcia-Alloza#br#   

  1. Division of Physiology, School of Medicine, Universidad de Cadiz, Cadiz, Spain (Alves-Martinez P, Garcia-Alloza M)
    Biomedical Research and Innovation Institute of Cádiz (INiBICA) Research Unit, Puerta del Mar University Hospital University of Cadiz, Cadiz, Spain (Alves-Martinez P, Garcia-Alloza M)
  • Online:2023-09-15 Published:2023-03-06
  • Contact: Monica Garcia-Alloza, PhD, monica.garcia@uca.es.
  • Supported by:
    The present work was supported by the following funds: To PAM: predoctoral fellowship. Instituto de Investigacion Biomedica de la Provincia de Cadiz (INIBICA). To MGA: Agencia Andaluza del Conocimiento. Proyectos I + D + I—Programa Operativo FEDER Andalucia 2014–2020 fondos FEDER (SOL201800107189-TRA). Agencia Estatal de Investigacion. Ministerio de Educacion y Ciencia. Programa Estatal de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I + D + i y del Programa Estatal de I + D + i Orientada a los Retos de la Sociedad, del Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2017–2020 (PID2020-115499RB-I00/AEI/10.13039/501100011033).

摘要: https://orcid.org/0000-0003-1610-4114 (Monica Garcia-Alloza) 

Abstract: There are around 15 million preterm newborns (PT) every year (Atienza-Navarro et al., 2020). With these figures in mind, prematurity represents a major health problem worldwide and it is a leading cause of infant mortality, accounting for up to 35% of all deaths among newborns (Atienza-Navarro et al., 2020) and up to 18% of the deaths among children under 5 years of age. Although advances in neonatology have significantly reduced mortality rates associated with prematurity, related comorbidities and sequelae remain a crucial societal and economic burden (Alves-Martinez et al., 2022). PT are born at a critical time in brain development, thus they have an immature central nervous system characterized by low neuronal migration, poor myelination, impaired grey matter growth matter or a fragile vascular structure of the germinal matrix (Atienza-Navarro et al., 2020), among others. The germinal matrix is a highly vascularized subependymal region adjacent to the ventricle. This tissue is prone to bleeding, due to the high vascularisation of the region and the hemodynamic instability of the PT (Atienza-Navarro et al., 2020), causing a germinal matrix-intraventricular hemorrhage (GM-IVH). GM-IVH is the most common intracerebral hemorrhage of the PT and affects up to 20–30% of these patients (Alves-Martinez et al., 2022). When GM-IVH occurs, neuronal loss, white matter lesions and inflammation are observed. The extension of the lesions, as well as related problems and sequelae, are highly dependent on the severity of the bleeding (Atienza-Navarro et al., 2020) and may include short- and long-term, neurological, sensory, cognitive and motor disabilities or neuropsychiatric disorders (Atienza-Navarro et al., 2020).