神经损伤与修复

    Axon regeneration: membrane expansion and lipidomics
  • Figure 1|Comparative lipidomics of optic nerve regeneration models.  

    As lipids facilitate membrane expansion, could lipidomic studies of axon regeneration provide insights into lipids involved in neuronal membrane expansion? Membrane expansion and lipid biogenesis insight is likely best obtained through evaluation of several CNS neuron regenerative models (optic nerve, spinal cord), rather than single or limited model studies (Figure 1). Focusing on a single regenerative factor may create intrinsic biases based on a factor’s specific signaling pathways. To understand axon regeneration as an overall process, it is better to evaluate many regenerative factors while controlling measurements and standardizing parameters, such as the length and volume of regrown axon, time post crush, transgenic nature of the animal, and the injury method used. We have discovered the importance of these lipidomic parameters as identifying significant lipid species can be difficult.


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  • 发布日期: 2021-12-08  浏览: 422
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