神经损伤与修复

    Coordination of Schwann cell myelination and node formation at the transcriptional level
  • Figure 1|Regulatory mechanism for the coordinated expression of myelin and nodal genes in myelinating glia. 

    Genome wide studies had furthermore shown that many of the Sox10-bound regions in the vicinity of myelin genes or genes with relevance for lipid biosynthesis (referred to as lipid biosynthetic genes) strongly overlap with regions that are occupied by Krox20 (also known as Egr2) in Schwann cells (Srinivasan et al., 2012). Considering the fact that loss-of-function experiments in the mouse established essential roles for both Sox10 and Krox20 in myelin formation, these data point to a cooperative transcriptional activation of myelin and lipid biosynthetic genes by Sox10 and Krox20 as a precondition for PNS myelination (Figure 1).


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  • 发布日期: 2021-12-17  浏览: 534
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