脑损伤
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Figure 1｜Neuroprotective function of N-acetyl-L-leucine (NALL) in traumatic brain injury (TBI).
Our study demonstrated functional improvements in both memory and motor skills and reduction in lesion volume in TBI mice treated with NALL (Figure 1). We expect this is primarily due to the observed attenuation of neurodegeneration and neuroinflammation following NALL treatment. These data support development of NALL as a potential future TBI treatment. However, additional preclinical assessments will be necessary, as our study has been carried out using only young male mice. Beneficial effects of NALL will need to be assessed in females and in aged mice of both sexes. The latter will be particularly important, as incidence of TBI is higher and outcomes worse among the elderly population.