脑损伤

    Alpha2-adrenergic receptor activation reinstates motor deficits in rats recovering from cortical injury
  • Figure 3| Percent change with respect to basal values obtained for the distance traveled by the sham and injured rats. 

    The effect of FeCl2-induced MC injury on the distance traveled is shown in Figure 3A and B. A decrease was noted in the mean percentage of motor spontaneous activity 8 hours after injury compared with the sham group (P = 0.0002), and this effect was maintained over the following 3 days (P = 0.0002). At 20 days post-injury, functional recovery was observed (P > 0.05). Figure 3B shows that the injured rats were able to walk, despite having displayed diminished spontaneous motor activity.


    Figure 5| Percent change with respect to basal values obtained for the distance traveled by sham and injured rats. 

    Figure 5A shows the effect of the CL, EF, and EF + CL treatments on spontaneous motor activity evaluated as distance traveled at 20 days post-injury. Systemic administration of the agonist CL significantly decreased the distance traveled by the injured group (P = 0.0003) compared with the sham group, and this effect was blocked by the coadministration of the antagonist EF. In the sham group, the administration of CL significantly decreased the distance traveled compared with the sham group that received the vehicle solution (P = 0.0002), and this effect was blocked by the coadministration of the antagonist EF. In both the sham and injured groups, the administration of EF alone did not exert a significant effect on the distance traveled at 20 days after FeCl2-induced injury (Figure 5A). Additionally, the effects of all treatments (vehicle, CL, EF, and CL + EF) mentioned above are shown in Figure 5B, with representative maps of the distance traveled at 20 days post-injury.

    Figure 7|Histological analysis of the locus coeruleus (LC).  

    Within the sham animals, α2A-positive NE cells were observed in the LC (Figure 7). In the injured rats, the immune signals for α2A-positive NE cells seemed more evident in the peripheral layers adjacent to the LC (Figure 7B and C). An increased staining area of α2A-positive NE cells was observed in the LC of injured rats (t = 2.3, P = 0.039; Figure 7D).

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  • 发布日期: 2022-10-31  浏览: 113
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