神经退行性病

    A candidate protective factor in amyotrophic lateral sclerosis: heterogenous nuclear ribonucleoprotein G
  • Figure 2|The distribution of hnRNP G in the anterior horn of the spinal cord of TG and WT mice at different stages. 


    Figure 3|The distribution of hnRNP G in the central canal and the surrounding gray matter of the spinal cord of TG and WT mice at different stages. 


    Figure 4|The distribution of hnRNP G in the posterior horn of the spinal cord of TG and WT mice at different stages.  


    The experimental overview is shown in Figure 1. We examined the distribution of hnRNPG-positive cells in sections of the spinal cord in the ALS model (TG) mice and WT mice at various time points: age 60–70 days (preonset of ALS), age 90–100 days (onset of ALS), and age 120–130 days (ALS progression) (Zhang et al., 2018a, b; Figures 2–4). 

    Figure 5|Double immunofluorescence staining of hnRNP G and NeuN in the anterior horn, the central canal and the surrounding gray matter and the posterior horn of different spinal cord segments of TG mice in the onset phase.   

    The hnRNP G antibody and the NeuN antibody (neuron marker) were used to double-label sections from the different spinal cord segments of mice in the onset TG group (Figure 5). We observed co-localization of hnRNP G and NeuN in different anatomic regions in the different spinal segments at the onset stage. These results showed that the hnRNP G was expressed in neurons of the spinal cord. 

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  • 发布日期: 2023-01-12  浏览: 154
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