脑损伤

    Maternal dietary deficiencies in folic acid or choline worsen stroke outcomes in adult male and female mouse offspring
  • Figure 4| Impact of maternal dietary deficiencies on offspring neuronal apoptosis and response to hypoxia in an ischemic brain region 1.5 months after photothrombotic surgery.  

    Within damaged ischemic tissue we assessed neurodegeneration in neurons by measuring active-caspase-3 levels. Representative images are shown in offspring in Figure 4A. Semi-quantification revealed reduced degeneration in males compared with females (F(1,11) = 7.0, P = 0.02). There was no maternal diet effect (F(2,12) = 0.16, P = 0.85). We also measured HIF-1α within the damage region and reported a similar reduction in neurons of male offspring (F(1,14) = 9.8, P = 0.007; Figure 4B). There was no maternal diet effect (F(2,14) = 2.8, P = 0.10).


    Figure 5| Impact of maternal dietary deficiency on ischemic stroke on ChAT in ischemic damage brain region 1.5 months after photothrombotic surgery. 

    To further investigate the impact of maternal deficient diets and ischemic stroke on choline metabolism, we measured levels of choline acetyltransferase within the ischemic brain region. Representative images are shown in Figure 5 and semi-quantification revealed a sex difference (F(1,12) = 7.0, P = 0.02).

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  • 发布日期: 2023-05-05  浏览: 108
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