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    The role of gap junctions in cell death and neuromodulation in the retina
  • Figure 1|Gap junction connections in the retina. 

    Both neuronal (ganglion cells, amacrine cells, bipolar cells, horizontal cells, and photoreceptors) and non-neuronal (astrocytes, microglia, and Müller cells) cell types tend to form gap junctions (GJs) that provide them with conduits for electrical and metabolic communication, thereby serving signaling and metabolism in health as well as in disease (Figure 1). This latter phenomenon has been central to a myriad of studies that identify GJs as possible key participants in developing disease phenotypes. In contrast, only a few studies refer to them as potential targets for regeneration or at least neuromodulation in the retina (Table 1). Their true contribution to cellular regeneration is yet to be unveiled.

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  • 发布日期: 2021-03-20  浏览: 568
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