视神经损伤

    Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system
  • Figure 1|Mechanisms involved in the contralateral response: the retino-retinal projection. 



    The mechanisms by which the contralateral response causes the degeneration of RGCs are not completely understood. Nadal-Nicolás et al. (2015b) and Ramírez et al. (2015) proposed some theories that alone or in combination could explain this effect: (1) the direct death of retino-retinal projecting RGCs (ret-ret RGCs) (Figure 1); (2) stress signals liberated by the damaged ret-ret RGCs that cause a neurotoxic environment in the contralateral retina (Figure 1); (3) the propagation of a glial reaction through the optic chiasm (Figure 2); (4) a retrograde degeneration spreading from the deafferentated retinorecipient areas in the brain (Figure 2); and/or (5) a systemic inflammatory reaction (Figure 3).


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  • 发布日期: 2021-04-20  浏览: 546
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