Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (14): 1333-1336.doi: 10.4103/1673-5374.137582

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Bridging long gap peripheral nerve injury using skeletal muscle-derived multipotent stem cells

Tetsuro Tamaki   

  1. Muscle Physiology & Cell Biology Unit, Department of Regenerative Medicine, Division of Basic Clinical Science, Tokai University School of
    Medicine, Isehara, Japan
  • Received:2014-07-04 Online:2014-07-25 Published:2014-07-25
  • Contact: Tetsuro Tamaki, Ph.D., Muscle Physiology and Cell Biology Unit, Department of Regenerative Medicine, Division of Basic Clinical Science, Tokai University School of Medicine, 143-Shimokasuya, Isehara, Kanagawa 259-1143, Japan,tamaki@is.icc.u-tokai.ac.jp.
  • Supported by:

    This work was supported by a 2013 Tokai University School of Medicine, Project Research Grant.

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Abstract:

Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells (Sk-MSCs) can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerve gap injury resulted favorable axonal regeneration, which showing superior effects than gold standard therapy--healthy nerve autograft. This means that it does not need to sacrifice of healthy nerves or loss of related functions for repairing peripheral nerve injury.

Key words: peripheral nerve support cells, Schwann cells, perineurium, endoneurium, cytokine, paracrine effect, blood vessel formation