Neural Regeneration Research ›› 2014, Vol. 9 ›› Issue (15): 1446-1452.doi: 10.4103/1673-5374.139461

Previous Articles     Next Articles

Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus

Wangxin Zhang 1, 2, Qiuling Zhang 2, Wen Deng 2, Yalu Li 2, Guoqing Xing 2, Xianjun Shi 2, Yifeng Du 1   

  1. 1 Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China
    2 Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China
  • Received:2014-05-05 Online:2014-08-12 Published:2014-08-12
  • Contact: Yifeng Du, M.D, Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong Province, China, duyifeng2013@163.com.
  • Supported by:

    This work was supported by the Natural Science Foundation of Taishan Medical University in China, No. 2007.ZR-087.

PDF

1020

Abstract:

Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both anti-oxidative and anti-inflammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion injury in rats. Our results showed that pretreatment with ganoderma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus, diminished the content of malondialdehyde in the hippocampus and serum, decreased the levels of tumor necrosis factor-α and interleukin-8 in the hippocampus, and increased the activity of superoxide dismutase in the hippocampus and serum. These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and anti-inflammatory actions.