Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (10): 1555-1557.doi: 10.4103/1673-5374.167748

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Regulation of axonal remodeling following spinal cord injury

Anne Jacobi, Florence M. Bareyre   

  1. Institute of Clinical Neuroimmunology, Ludwig-Maximilians Universität München, Munich, Germany (Jacobi A, Bareyre FM)
    Munich Cluster of Systems Neurology (SyNergy), Munich, Germany (Bareyre FM)
  • Received:2015-09-16 Online:2015-10-28 Published:2015-10-28
  • Contact: Florence M. Bareyre, Ph.D.,florence.bareyre@med.uni-muenchen.de.
  • Supported by:

    Work in FMB laboratory is supported by grants from the Deutsche Forschungsgemeinschaft (DFG, SFB870) and by the Munich Center for System Neurology (SyNergy, EXC1010). The authors thank Martin Kerschensteiner for critically reading the paper.

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Abstract:

Timely and accurate axonal remodeling is key to functional recovery following spinal cord injury. To therapeutically support such remodeling processes in the future we first have to unravel the molecular signals that govern their endogenous formation. Recent studies such as the ones described here identify first molecular clues but much more work is required to obtain a comprehensive molecular understanding of circuit remodeling in the injured spinal cord.