The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system

doi:10.4103/1673-5374.170325

Neural Regeneration Research ›› 2015, Vol. 10 ›› Issue (11): 1892-1896.doi: 10.4103/1673-5374.170325

The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system

Jing Liu^{1, *}, Hong-yan Gao¹, Xiao-feng Wang^{1, 2}

1 Department of Neonatology & NICU of Bayi Children’s Hospital, General Hospital of Beijing Military Command of Chinese PLA, Beijing, China
2 Department of Neonatology, People’s Hospital of Rizhao, Rizhao, Shangdong Province, China

Received:2015-06-17 Online:2015-12-07 Published:2015-12-07
Contact: Jing Liu, M.D., liujingbj@live.cn.
Supported by:
This research was supported by a grant from the National Natural Science Foundation of China, No. 81471087, 81170577.

Abstract

Abstract:

The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore,
a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system.

Key words: nerve regeneration, Rho/Rho-associated coiled-coil containing protein kinase, signaling pathway, axonal regeneration, central nervous system, microenvironment, reviews, NSFC grant, neural regeneration

Jing Liu, Hong-yan Gao, Xiao-feng Wang. The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system[J]. Neural Regeneration Research, 2015, 10(11): 1892-1896.

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The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system

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