Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (10): 1610-1616.doi: 10.4103/1673-5374.193240

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Hydroxycitric acid ameliorates in?ammation and oxidative stress in mouse models of multiple sclerosis

Mahdi Goudarzvand1, Sanaz Afraei2, *, Somaye Yaslianifard3, Saleh Ghiasy4, Ghazal Sadri4, Mustafa Kalvandi1, Tina Alinia4, Ali Mohebbi5, Reza Yazdani6, Shahin Khadem Azarian2, Abbas Mirshafey2, Gholamreza Azizi7, 4, *   

  1. 1 Department of Physiology and Pharmacology, Faculty of Medicine, Alborz University of Medical Sciences, Karaj, Iran 2 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 3 Department of Microbiology and Immunology, School of Medicine,Alborz University of Medical Sciences, Karaj, Iran 4 Research Centre for Immunodefciencies, Pediatrics Centre of Excellence, Children’s Medical Centre, Tehran University of Medical Sciences, Tehran, Iran 5 Growth and Development Research Centre, Paediatrics Centre of Excellence, Children’s Medical Centre, Tehran University of Medical Sciences, Tehran, Iran 6 Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 7 Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran
  • Received:2016-09-18 Online:2016-10-31 Published:2016-10-31
  • Contact: Gholamreza Azizi, Ph.D. or Sanaz Afraei, M.Sc., azizi_g@razi.tums.ac.ir or Sanaz_afraei@yahoo.com.
  • Supported by:
    This work was supported by Vice Chancellor for Research, Alborz University of Medical Sciences, No. 1394-01-01-1050.

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Abstract: Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-in?ammatory e?ects. Multiple sclerosis can cause an in?ammatory demyelination and axonal damage. In this study, to validate the hypothesis that HCA exhibits therapeutic e?ects on multiple sclerosis, we established female C57BL/6 mouse models of multiple sclerosis, i.e., experimental autoimmune encephalomyelitis, using Complete Freund’s Adjuvant (CFA) emulsion containing myelin oligodendrocyte glycoprotein (35–55). Treatment with HCA at 2 g/kg/d for 3 weeks obviously improved the symptoms of nerve injury of experimental autoimmune encephalomyelitis mice, decreased serum interleulin-6, tumor necrosis factor alpha, nitric oxide, and malondialdehyde levels, and increased superoxide dismutase and glutathione reductase activities. Tese fndings suggest that HCA exhibits neuroprotective e?ects on multiple sclerosis-caused nerve injury through ameliorating in?ammation and oxidative stress.

Key words: nerve regeneration, hydroxycitric acid, multiple sclerosis, in?ammation, oxidative stress, experimental autoimmune encephalomyelitis, neural regeneration