Neural Regeneration Research ›› 2016, Vol. 11 ›› Issue (10): 1644-1652.doi: 10.4103/1673-5374.193245

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Preparation of polypyrrole-embedded electrospun poly(lactic acid) nanofbrous sca?olds for nerve tissue engineering

Jun-feng Zhou1, #, Yi-guo Wang2, 3, #, Liang Cheng1, Zhao Wu1, Xiao-dan Sun1, *, Jiang Peng2, 4, *   

  1. 1 Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing, China 2 Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China 3 School of Medicine, Nankai University, Tianjin, China 4 Te Neural Regeneration Co-innovation Center of Jiangsu Province, Nantong, Jiangsu Province, China
  • Received:2016-09-01 Online:2016-10-31 Published:2016-10-31
  • Contact: Xiao-dan Sun or Jiang Peng, sunxiaodan@mail.tsinghua.edu.cn or pengjiang301@126.com.
  • Supported by:
    This research was fnancially supported by Tsinghua University Initiative Scientifc Research Program, No. 20131089199; the National Key Research and Development Program of China, No. 2016YFB0700802; the National Program on Key Basic Research Project of China (973 Program), No. 2012CB518106, 2014CB542201.

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Abstract: Polypyrrole (PPy) is a biocompatible polymer with good conductivity. Studies combining PPy with electrospinning have been reported; however, the associated decrease in PPy conductivity has not yet been resolved. We embedded PPy into poly(lactic acid) (PLA) nanofbers via electrospinning and fabricated a PLA/PPy nanofbrous sca?old containing 15% PPy with sustained conductivity and aligned topography. Tere was good biocompatibility between the sca?old and human umbilical cord mesenchymal stem cells as well as Schwann cells. Additionally, the direction of cell elongation on the sca?old was parallel to the direction of fbers. Our fndings suggest that the aligned PLA/PPy nanofbrous sca?old is a promising biomaterial for peripheral nerve regeneration.

Key words: nerve regeneration, polypyrrole, electrospinning, conductivity, electrical property, Schwann cells, human umbilical cord mesenchymal stem cells, nerve tissue engineering, nanofbrous sca?olds, neural regeneration