Neural Regeneration Research ›› 2012, Vol. 7 ›› Issue (22): 1729-1735.

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Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury

Jian Huo, Jiachuan Liu, Jinbiao Wang, Yongming Zhang, Chunlin Wang, Yanyan Yang, Wenjiang Sun, Shaonian Xu   

  1. Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China
  • Received:2012-01-06 Revised:2012-05-26 Online:2012-08-05 Published:2012-08-05
  • Contact: Jiachuan Liu, Master, Chief physician, Master’s supervisor, Department of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China ljc571017@sina.com
  • About author:Jian Huo★, Master, De-partment of Neurosurgery, the 105 Hospital of Chinese PLA, Hefei 230032, Anhui Province, China

Abstract:

In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blast- induced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

Key words: hyperbaric oxygen, blast-induced injury, craniocerebral injury, aquaporin 4, pituitary gland, adrenocorticotropic hormone