Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 527-528.doi: 10.4103/1673-5374.346053

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Developmental exposure to thyroid disruptors: misprogramming of the brain’s stem cells in later life?

Pieter Vancamp, Sylvie Remaud*   

  1. Laboratory of Molecular Physiology and Adaptation, CNRS UMR 7221, Department Adaptations of Life, Muséum National d’Histoire Naturelle, Paris, France
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Sylvie Remaud, PhD, sremaud@mnhn.fr.
  • Supported by:
    PV and SR are supported by the European Union’s Horizon 2020 contract ATHENA (grant No. 666869) and ENDpoiNTs (grant No. 825759). PV was additionally supported by the European Thyroid Association (ETA) and the Fondation pour la Recherche Médicale (FRM grant No. SPF201909009111).

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Abstract: Ever since the discovery of neural stem cells (NSCs) in the adult mammalian brain, scientists have been trying to decipher which signals govern their turnover and lineage commitment to generate neurons and glia. Understanding their role in nervous tissue homeostasis can provide new insights into the etiology of several neurological disorders, and might one day be turned to our advantage to promote endogenous brain injury repair. Others and we have identified thyroid hormone (TH) as a key factor transcriptionally regulating NSC behavior in the largest niche of the adult mammalian brain: the subventricular zone (SVZ).