Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 531-532.doi: 10.4103/1673-5374.346488

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Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes

Clara Alice Musi, Carlo Bonadonna, Tiziana Borsello*   

  1. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy (Musi CA, Bonadonna C, Borsello T)
    Mario Negri Insitute for Pharmacolgical Research – IRCCS, Milano, Italy (Musi CA, Borsello T)
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Tiziana Borsello, PhD, tiziana.borsello@unimi.it
  • Supported by:
    This work was funded by Ricerca Finalizzata 2016 RF-2016-02361941, MIUR, -PON “Ricerca e Innovazione” PerMedNet id project ARS01_01226-PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE Prot. 2017MYJ5TH and 312 European Commission’s Horizon 2020 research and innovation program, No. 847749.

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Abstract: Brain synapses play a key role in neuronal communication: this “conversation” is at the basis of all brain activities and synaptic dysfunction leads to brain disorders. We study the modulators of this crucial synaptic function and we here present the evidence supporting the c-Jun N-terminal kinase (JNK) pathway as a pivotal actor in this scenario.