Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 535-536.doi: 10.4103/1673-5374.346485

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CD34+ progenitor cells as diagnostic and therapeutic targets in Alzheimer’s disease

Daniel Romaus-Sanjurjo*, Antía Custodia, Alberto Ouro, Tomás Sobrino*   

  1. NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Daniel Romaus-Sanjurjo, PhD, daniel.romaus.sanjurjo@sergas.es; Tomás Sobrino, PhD, tomas.sobrino.moreiras@sergas.es.
  • Supported by:
    This work was partially supported by grants from the Xunta de Galicia (IN607A2018/3 to TS, IN607D 2020/09 to TS, IN606A-2021/015 to AC; IN606B-2021/010 to DRS), and Science Ministry of Spain (RTI2018-102165-B-I00 to TS, RTC2019-007373-1 to TS). Furthermore, this work was also supported by grants from the INTERREG Atlantic Area (EAPA_791/2018_ NEUROATLANTIC project to TS), INTER-REG V A España Portugal (POCTEP) (0624_2IQBIONEURO_6_E to TS), and the European Regional Development Fund (ERDF). Moreover, DRS (CD21/00166) and TS (CPII17/00027) are recipients of research contracts from the Sara Borrell and Miguel Servet Programs, respectively, from the Instituto de Salud Carlos III. 

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Abstract: Alzheimer’s disease (AD) is the main neurodegenerative disease leading to dementia and cognitive impairment in the elderly. Considering AD to be an epidemic, an increase from the current 50 million to more than 150 million patients is expected by the year 2050. AD is characterized by a slow, progressive and asymptomatic onset; making it difficult to decipher the precise etiology. It is well established that AD presents two characteristic features, extracellular β-amyloid plaques and intracellular tau tangles, that eventually lead to the impairment of cognitive functions. Unfortunately, AD symptomatology shares many similarities with other dementias once is present, which makes it difficult an accurate premortem diagnosis.