Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (3): 543-544.doi: 10.4103/1673-5374.346481

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Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?

Kate Beecher, Julie A. Wixey*   

  1. UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia
  • Online:2023-03-15 Published:2022-08-26
  • Contact: Julie A. Wixey, PhD, j.wixey@uq.edu.au.
  • Supported by:
    This work was supported by The University of Queensland Stimulus Fellowship (to JAW), and Queensland Children’s Hospital Foundation Grant (No. WIS0012021, to support KB).

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Abstract: Fetal growth restriction (FGR) describes a fetus that has not grown to its expected biological potential in utero. FGR can result from maternal, fetal, or placental complications, though it is commonly caused by placental insufficiency. The prolonged hypoxic environment the FGR fetus is exposed to has detrimental effects on the newborn, which extends to adverse long-term neurological outcomes in a significant proportion of FGR infants (Malhotra et al., 2019). Unfortunately, there are currently no therapies to reduce the adverse neurological outcomes in FGR. Neuronal injury is evident in the FGR brain, and therefore understanding which neurons are lost and how they are lost will aid in the selection of treatment options for FGR.