Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (6): 1265-1266.doi: 10.4103/1673-5374.358621

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Neural regeneration research model to be explored: SH-SY5Y human neuroblastoma cells

Lavynia Ferreira Hoffmann, Alexandre Martins, Fernanda Majolo, Verônica Contini, Stefan Laufer, Márcia Inês Goettert*#br#   

  1. Graduate Program in Biotechnology, University of Vale do Taquari (Univates), Lajeado, Rio Grande do Sul, Brazil (Hoffmann LF, Martins A, Contini V, Goettert MI) 
    Graduate Program in Medical Sciences - PPGCM, University of Vale do Taquari - Univates, Lajeado/RS, Brazil (Majolo F, Contini V, Goettert MI) 
    Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery - TÜCADD, Eberhard Karls University Tübingen, Tübingen, Germany (Laufer S, Goettert MI) 
  • Online:2023-06-15 Published:2022-12-22
  • Contact: Márcia Inês Goettert, PhD, m.goettert@uni-tuebingen.de or stefan.laufer@uni-tuebingen.de.
  • Supported by:
    This work was supported in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes-Brazil), No. 001 (to MIG). 

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Abstract: In neuroscience research, neuronal models are crucial tools for elucidating the molecular and cellular processes involved in the disorders of the nervous system. Facilitating easily and reproducibly executable studies, in vitro models, such as the SH-SY5Y cell line culture, help us explore the pathophysiological mechanisms of neurodegenerative diseases; they are also essential for the efficient screening of drugs for treating the diseases of the nervous system (Peng et al., 2021; Strother et al., 2021).