Abstract: Stem cells may be the future of therapeutics for stroke due to their regenerative and immunomodulatory capabilities. Major barriers faced when employing stem cells, however, include faulty migration, low cell survival, and diminished proliferation. Multilineage-differentiating stress ensuring (Muse) cells, a subset of mesenchymal stem cells, overcome these barriers. Muse cells aid in neuroregeneration, have immense regenerative potential, and are pluripotent, non-tumorigenic, and immunomodulatory. In stroke specifically, these cells may restore an anti-inflammatory environment, regenerate damaged neurons, and integrate into the neuronal architecture. In fact, Muse cells may be aptly designed to ameliorate neurovascular unit damage following stroke and observed in other neuroinflammatory disorders.