Neural Regeneration Research ›› 2023, Vol. 18 ›› Issue (12): 2762-2766.doi: 10.4103/1673-5374.373659

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Nerve function restoration following targeted muscle reinnervation after varying delayed periods

Yuanheng Li1, #, Jiangping Huang1, #, Yuling Chen2, 3, Shanshan Zhu1, Zhen Huang2, 3, Lin Yang1, *, Guanglin Li1, *   

  1. 1Key Laboratory of Human-Machine Intelligence-Synergy Systems and Branch of Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China; 2Department of Rehabilitation Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China; 3Department of Rehabilitation Medicine, Yibin Hospital of Traditional Chinese Medicine, Yibin, Sichuan Province, China
  • Online:2023-12-15 Published:2023-06-16
  • Contact: Guanglin Li, PhD, gl.li@siat.ac.cn; Lin Yang, PhD, aiyzwll@aliyun.com.
  • Supported by:
    This work was supported in part by the National Natural Science Foundation of China, Nos. U1913601, 81927804; the Key-Area Research and Development Program of Guangdong Province, No. 2020B0909020004 (GL); the National Natural Science Foundation of China, Nos. 81960419, 82260456 (both to LY).

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Abstract: Targeted muscle reinnervation has been proposed for reconstruction of neuromuscular function in amputees. However, it is unknown whether performing delayed targeted muscle reinnervation after nerve injury will affect restoration of function. In this rat nerve injury study, the median and musculocutaneous nerves of the forelimb were transected. The proximal median nerve stump was sutured to the distal musculocutaneous nerve stump immediately and 2 and 4 weeks after surgery to reinnervate the biceps brachii. After targeted muscle reinnervation, intramuscular myoelectric signals from the biceps brachii were recorded. Signal amplitude gradually increased with time. Biceps brachii myoelectric signals and muscle fiber morphology and grooming behavior did not significantly differ among rats subjected to delayed target muscle innervation for different periods. Targeted muscle reinnervation delayed for 4 weeks can acquire the same nerve function restoration effect as that of immediate reinnervation. 

Key words: biceps brachii, delayed nerve repair, delayed targeted muscle reinnervation, functional reconstruction, grooming test, implanted electrode, intramuscular myoelectric signals, median nerve, motor function, nerve transfer