Abstract: Brain organoids mimic closely the embryonic human brain: Over the last decade, the development of human organoid systems has evolved rapidly. Different tissues have been modeled with organoids, such as the gut, lung, liver, kidney retina and brain. These systems have a high cellular heterogeneity, with many cell types integrated into the same system. Organoids’ cellular populations interact between and amongst each other in a cellular and molecular level, which represents an advantage with respects to monolayer 2D cell culture systems.