Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (2): 395-396.doi: 10.4103/1673-5374.379047

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Astrocyte syncytium: from neonatal genesis to aging degeneration

Min Zhou*, Shiying Zhong, Alexei Verkhratsky*#br#   

  1. Department of Neuroscience, Ohio State University Wexner Medical Center, Columbus, OH, USA (Zhou M, Zhong S) 
    Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK (Verkhratsky A) 
    Achücarro Basque Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain (Verkhratsky A) 
    Department of Neurosciences, University of the Basque Country UPV/EHU and CIBERNED, Leioa, Spain (Verkhratsky A)
  • Online:2024-02-15 Published:2023-08-30
  • Contact: Min Zhou, MD, PhD, zhou.787@osu.edu; Alexei Verkhratsky, MD, PhD, Dr Sc, Alexej.Verkhratsky@manchester.ac.uk.
  • Supported by:
    This work was sponsored by a grant from the National Institute of Neurological Disorders and Stroke: RO1NS116059 (to MZ).

Abstract: Modern neuroscience began from all reaching and fierce conflict between “neuronismo and reticulismo” – between neuronal and reticular theories of the organization of the nervous system; the conflict culminated in December of 1906 in Stockholm where Santiago Ramon y Cajal (the proponent of the neuronal doctrine) and Camillo Golgi (who advocated the syncytial reticular organization of neural networks) delivered their Noble prize lectures (Verkhratsky, 2009). The neuronal doctrine eventually was victorious and dominated 20th-century neuroscience and neurology. As frequently happens in science, the views of both Cajal and Golgi were correct, and as we know now the central nervous system (CNS) comprises highly coordinated networks of synaptically connected neurons and gap junction-connected neuroglia, the latter being the syncytial or reticular portion of the nervous tissue (Kiyoshi and Zhou, 2019).