Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (2): 407-408.doi: 10.4103/1673-5374.377607

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Treadmill training in Parkinson’s disease: possible role of prefrontal modifications in the improved cortical-subcortical network function

Hao Ding, Amgad Droby, Abdul Rauf Anwar, Jeffrey M. Hausdorff, Bahman Nasseroleslami, Anat Mirelman, Inbal Maidan*, Muthuraman Muthuraman*#br#   

  1. Department of Neurology, University Hospital Würzburg, Würzburg, Germany (Ding H, Muthuraman M)
    Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin, Ireland (Ding H, Nasseroleslami B)
    Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (Droby A, Mirelman A, Maidan I)
    Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel (Droby A, Hausdorff JM, Mirelman A, Maidan I)
    Biomedical Engineering Centre, UET Lahore (KSK Campus), Lahore, Pakistan (Anwar AR)
    Laboratory for Early Markers of Neurodegeneration (LEMON), Center for the Study of Movement, Cognition, and Mobility (CMCM), Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (Droby A, Hausdorff JM, Mirelman A, Maidan I)
    Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (Hausdorff JM)
    Rush Alzheimer’s Disease Center and Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA (Hausdorff JM)
  • Online:2024-02-15 Published:2023-08-30
  • Contact: Inbal Maidan, PhD, inbalm@tlvmc.gov.il; Muthuraman Muthuraman, PhD, Muthuraman_M@ukw.de.
  • Supported by:
    This work was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), No. 424778381-TRR 295 (to MM).

Abstract: Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by a range of motor symptoms such as bradykinesia, resting tremor, rigidity, and postural instability, as well as non-motor symptoms, such as depression, anxiety, sleep disturbances, and fatigue (Bloem et al., 2021). The underlying pathology involves a progressive loss of dopamine neurons within the substantia nigra, which results in an imbalance between the direct and indirect pathways of the basal ganglia that regulate motor control (Bloem et al., 2021). In addition to pharmacological treatments such as dopamine replacement therapy, non-pharmacological interventions have been investigated in alleviating gait and motor abnormalities in individuals with PD. The use of behavioral interventions in conjunction with pharmacological therapies may offer a more comprehensive approach to managing the motor symptoms of PD. In recent years, neuroimaging techniques have been utilized to explore neural fingerprints of various behavioral interventions (Mak and Wong-Yu, 2019). These techniques have helped elucidate the complex interplay between brain structure and function in PD, offering valuable comprehension of how behavioral approaches could potentially alleviate the motor symptoms of this debilitating disease.