Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (7): 1414-.doi: 10.4103/1673-5374.387995

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Medin synergized with vascular amyloid-beta deposits accelerates cognitive decline in Alzheimer’s disease: a potential biomarker

Xiao Ge, Li Li, Chunming Xie*   

  1. Department of Neurology, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China (Ge X, Xie C) 
    Center of Health Management, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China (Li L)
    Institute of Neuropsychiatry, Affiliated Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, China (Xie C)
    The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, Jiangsu Province, China (Xie C)
  • Online:2024-07-15 Published:2023-11-28
  • Contact: Chunming Xie, MD, PhD, chmxie@163.com.
  • Supported by:
    This work was supported by the Science and Technology Innovation 2030-Major Projects, No. 2022ZD0211600 and the National Natural Science Foundation of China, Nos. 82271574 and 82071204 (all to CX).

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Abstract: Brain vascular dysfunction in Alzheimer’s disease (AD) pathogenesis has become increasingly clear. Accumulating evidence shows that damaged vascular, including large or small vessels and even neurovascular unit, may accelerate the neuropathological process of AD via disrupting brain hypoperfusion, aberrant angiogenesis, and neuroinflammatory response, etc. Thus, vascular dysfunction makes a substantially contribution to the cognitive decline of AD patients. However, how these blood vessels and pathological markers of AD link or interact to influence cognitive function remains unclear.