Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (10): 2101-2102.doi: 10.4103/1673-5374.392879

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Cognition and movement in neurodegenerative disorders: a dynamic duo#br#

Marit F.L. Ruitenberg*   

  1. Department of Health, Medical and Neuropsychology, Leiden University, Leiden, the Netherlands
    Leiden Institute for Brain and Cognition, Leiden, the Netherlands
  • Online:2024-10-15 Published:2024-01-29
  • Contact: Marit F.L. Ruitenberg, PhD, m.f.l.ruitenberg@fsw.leidenuniv.nl.

Abstract: People with neurodegenerative disorders often experience problems across a variety of functional domains, including cognition, movement, and psychosocial functioning. The classification of these disorders is based on the phenotypical manifestations that represent the most prominent clinical features. For example, Parkinson’s disease and Huntington’s disease are typically regarded as movement disorders, whereas Alzheimer’s disease (AD) and other dementias are regarded as cognitive disorders. A problem with this classification is that it seems to disregard the fact that cognition and movement are actually strongly linked – successful motor performance does not only require the direct, physical control of muscles by the musculoskeletal system to generate movement and stability, but also involves cognitive control processes that allow us to engage in goal-directed behavior in the face of uncertain and/or changing environments (Abrahamse et al., 2013; McDougle et al., 2016). As a result, it seems difficult (if not impossible) to separate between “pure” motor or cognitive conditions. In this perspective article, I therefore propose that we should consider abandoning the classical movement versus cognitive disorder dichotomy when it comes to classifying neurodegenerative diseases.