Neural Regeneration Research ›› 2024, Vol. 19 ›› Issue (10): 2111-2112.doi: 10.4103/1673-5374.392885

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Going straight for the gut: gut-brain axis pathology and treatment of Parkinson’s disease

Dominique Ebedes, Cesar V. Borlongan#br#   

  1. University of South Florida Morsani College of Medicine, Tampa, FL, USA (Ebedes D) 
    Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA (Borlongan CV)
  • Online:2024-10-15 Published:2024-01-29
  • Contact: Cesar V. Borlongan, PhD, cborlong@health.usf.edu.

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Abstract: This perspective focuses on the recent literature regarding the role of the gut-brain axis (GBA) in fecal microbiota transplantation (FMT) and stem cell therapy (SCT) in Parkinson’s disease (PD). PD is the second most common neurodegenerative disease in the United States, yet therapies remain limited. Current research suggests that the GBA may play a role in the pathogenesis of PD. GBA-based FMT as well as SCT offer promising new avenues for PD treatment. Probing the interactions between FMT and SCT with the GBA may reveal novel therapeutics for PD.