Abstract: Obesity represents a major global health concern, with widespread growing prevalence and severe consequences for the quality of life and life expectancy of affected individuals and for the economic burden of healthcare systems (Prospective Studies Collaboration, 2009). Obesity is a well-established risk factor for a variety of conditions including metabolic, vascular, and heart diseases, and several types of cancer (Prospective Studies Collaboration, 2009). In addition, in the past few decades, accumulating clinical and epidemiological evidence associates obesity with cognitive decline and a higher risk for developing neurodegenerative and neuropsychiatric disorders such as Alzheimer’s disease (AD), anxiety, and depression. A recent large-scale cross-sectional study concluded that midlife obesity is now the most prominent modifiable risk factor for developing AD and related dementia in the US (Nianogo et al., 2022). Further evidence from a prospective study with 1 million UK women (mean age of 56 years at baseline) shows that a body mass index (the anthropometric marker for obesity) > 30 kg/m2 at baseline was associated with a higher incidence of dementia 15 years later (Floud et al., 2018).