Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (1): 67-81.doi: 10.4103/1673-5374.393104

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke: current evidence and future perspectives

Yubo Wang1, 2, #, Tingli Yuan3, #, Tianjie Lyu1, 2, #, Ling Zhang1, Meng Wang2, 4, Zhiying He3, 5, *, Yongjun Wang1, 2, 4, 6, 7, 8, *, Zixiao Li1, 2, 4, 6, 7, 8, *   

  1. 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 2China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 3Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, China; 4National Center for Healthcare Quality Management in Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; 5Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; 6Chinese Institute for Brain Research, Beijing, China; 7Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, China; 8Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases, Beijing, China
  • Online:2025-01-15 Published:2025-01-15
  • Contact: Zhiying He, PhD, zyhe@tongji.edu.cn; Yongjun Wang, PhD, MD, yongjunwang@ncrcnd.org.cn; Zixiao Li, PhD, MD, lizixiao2008@hotmail.com.
  • Supported by:
    This work was supported by grants from the Major Program of National Key Research and Development Project, Nos. 2020YFA0112600 (to ZH); the National Natural Science Foundation of China, No. 82171270 (to ZL); Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry, Ministry of Industry and Information Technology of the People's Republic of China, No. 2020-0103-3-1 (to ZL); the Natural Science Foundation of Beijing, No. Z200016 (to ZL); Beijing Talents Project, No. 2018000021223ZK03 (to ZL); Beijing Municipal Committee of Science and Technology, No. Z201100005620010 (to ZL); CAMS Innovation Fund for Medical Sciences, No. 2019-I2M-5-029 (to YW); and Shanghai Engineering Research Center of Stem Cells Translational Medicine, No. 20DZ2255100 (to ZH).

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Abstract: Ischemic stroke is a leading cause of death and disability worldwide, with an increasing trend and tendency for onset at a younger age. China, in particular, bears a high burden of stroke cases. In recent years, the inflammatory response after stroke has become a research hotspot: understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its treatment. This review summarizes several major cells involved in the inflammatory response following ischemic stroke, including microglia, neutrophils, monocytes, lymphocytes, and astrocytes. Additionally, we have also highlighted the recent progress in various treatments for ischemic stroke, particularly in the field of stem cell therapy. Overall, understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient outcomes. Stem cell therapy may potentially become an important component of ischemic stroke treatment.

Key words: cell therapy, immune cell, inflammatory, ischemic stroke, stem cell