Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (1): 184-185.doi: 10.4103/NRR.NRR-D-23-01637

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Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain

Teruyuki Ishikura, Tatsusada Okuno*   

  1. Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan (Ishikura T) 
    Department of Neurology, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan (Okuno T)
  • Online:2025-01-15 Published:2024-01-15
  • Contact: Tatsusada Okuno, MD, PhD, okuno@neurol.med.osaka-u.ac.jp.

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Abstract: In this article, we present our previous research, which highlighted adenosine triphosphate (ATP) as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder (NMOSD). In NMOSD pathology, damage-associated molecular patterns (DAMPs), including ATP, are released from damaged astrocytes, triggering the activation of innate immune cells. ATP is a central mediator of acute pain in NMOSD. We delve into the mechanisms of ATP in peripheral neuropathic pain, drawing comparisons with our findings in NMOSD. Additionally, we address the intricacies of chronic pain associated with NMOSD.