Abstract: The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of previously replication-competent cells. Many stress situations lead to senescence, including telomere shortening, genotoxic stress, oncogene- and oxidative-induced stress, and mitochondrial dysfunction (Mico et al., 2021). It is also characterized by a proinflammatory senescence-associated secretory phenotype (SASP) that potentiates chronic low-grade inflammation and inflammaging-associated dysfunction, resulting in loss of tissue function and health (Figure 1; Mico et al., 2021).