Neural Regeneration Research ›› 2018, Vol. 13 ›› Issue (3): 423-424.doi: 10.4103/1673-5374.228722

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Immunomodulation as a neuroprotective strategy after spinal cord injury

Susana Monteiro1, 2, António J. Salgado1, 2, Nuno A. Silva1, 2   

  1. 1 Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, Braga, Portugal;
    2 ICVS/3B’s – PT Government Associate Laboratory, Braga/Guimarães, Portugal
  • Received:2018-02-10 Online:2018-03-15 Published:2018-03-15
  • Contact: Nuno A. Silva, Ph.D., nunosilva@med.uminho.pt.
  • Supported by:

    The study was supported by Prémios Santa Casa Neurociências—Prize Meloe Castro for Spinal Cord Injury Research; Portuguese Foundation for Science and Technology (Financiado no âmbito do Projecto 3599—Promover a Produção Científica e Desenvolvimento Tecnológico e a Constituição de Redes Temáticas (3599-PPCDT), project: PTDC/DTP-FTO/5109/2014; Post-Doctoral fellowship—SFRH/BPD/97701/2013—to N.A. Silva; IF Development Grant to A. J. Salgado).

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Abstract:

The initial trauma to the spinal cord is just the starting point for a cascade of endogenous events that will collectively determine the injury extension.These secondary events include, but are not limited to: glutamate excitoxicity,induction of apoptotic pathways, ionic imbalances and the development of a strong and dysfunctional inflammatory response. The secondary injury is associated to an aggravation of neuronal damage increasing the extent of neurological deficits (Ek et al., 2010).