Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (4): 1098-1100.doi: 10.4103/NRR.NRR-D-24-00064

Previous Articles     Next Articles

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

Jae-Hong Kim#, Ruqayya Afridi#, Il-Sung Jang, Maan Gee Lee, Kyoungho Suk*   

  1. Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, School of Medicine, Kyungpook National University, Daegu, Republic of Korea (Kim JH, Afridi R, Suk K)  Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea (Kim JH, Afridi R, Lee MG, Suk K)  Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea (Jang IS)  Brain Science & Engineering Institute, Kyungpook National University, Daegu, Republic of Korea (Jang IS, Lee MG, Suk K)
  • Online:2025-04-15 Published:2024-07-03
  • Contact: Kyoungho Suk, PhD,ksuk@knu.ac.kr.
  • Supported by:
    This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (2017R1A5A2015391 and 2020M3E5D9079764) (to KS).

PDF

25

Abstract: Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan. The astrocytic regulation of neuronal activity has been increasingly recognized in recent years. Astrocytes are now recognized as playing a more complex role than mere bystanders in the central nervous system. However, their role in regulating the sleep neurocircuitry is not well understood. From this perspective, we highlight the role of astrocytes in sleep modulation, with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus (VLPO) of the hypothalamus. We briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.