Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (8): 2307-2308.doi: 10.4103/NRR.NRR-D-24-00493

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Impact of Zika virus non-structural protein mutations on hippocampal damage

Larissa M. G. Cassiano, Roney S. Coimbra*   

  1. Neurogenômica/Imunopatologia, Instituto René Rachou, Fiocruz, Belo Horizonte, Brazil (Cassiano LMG, Coimbra RS) Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (Cassiano LMG)
  • Online:2025-08-15 Published:2024-12-13
  • Contact: Roney S. Coimbra, PhD, roney.coimbra@fiocruz.br.
  • Supported by:
    This work was supported by INOVA Fiocruz and INCT Vacinas (to RSC).

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Abstract: The Zika virus (ZIKV), a member of the Flaviviridae family, attracted worldwide attention for its connection to severe neurological effects, notably microcephaly in newborns, first reported during the 2015 epidemic in Brazil. Yet, its impact goes beyond fetal and neonatal abnormalities, also affecting the central nervous system (CNS) in both children and adults, leading to enduring cognitive and behavioral impairments