Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (8): 2321-2322.doi: 10.4103/NRR.NRR-D-24-00200

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Making bridges between preclinical and clinical insights into age-related cognitive decline

David VC Brito, Clévio Nóbrega*   

  1. Algarve Biomedical Center-Research Institute (ABC-RI), Campus Gambelas, Faro, Portugal (Brito DVC, Nóbrega C) Algarve Biomedical Center- (ABC), Campus Gambelas, Faro, Portugal (Brito DVC, Nóbrega C) Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Gambelas Campus, Faro, Portugal (Nóbrega C)
  • Online:2025-08-15 Published:2024-12-13
  • Contact: Clévio Nóbrega, PhD, cdnobrega@ualg.pt.
  • Supported by:
    Clévio Nóbrega’s laboratory is funded by the Cure CSB project, by the Viljem Julijan Association for Children with Rare Diseases (Slovenia), and by the Algarve Biomedical Center Research Institute (ABC-Ri). The project was also funded by CRESC Algarve 2020 (Operation Code: ALG-01–0145- FEDER-072586) (to CN)

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Abstract: With people living longer, the societal impact of age-related cognitive decline is becoming more pronounced (Crimmins, 2015). Thus, it is increasingly important to comprehend the cognitive shifts linked to aging – whether they are physiological or pathological. Neurodegenerative disorders are particularly prevalent in older individuals, as the incidence of these conditions is positively correlated with age. However, gene mutations can accelerate the onset of age-related cognitive decline (Pan et al., 2021). Even individuals without dementia, may experience subtle changes in cognition as they grow older, estimated to affect around 20% of older adults (Pais et al., 2020; Chen et al., 2023). Recognizing these cognitive alterations is essential because they can influence an elderly person’s daily functioning and assist in distinguishing between normal aging and illness (Harada et al., 2013). Furthermore, emerging evidence suggests that individuals experiencing agerelated cognitive decline without disease exhibit higher rates of hospitalizations and increased risk for adverse effects (Fogg et al., 2018; Amini et al., 2019). Therefore, it is essential to identify the structural and functional changes responsible for these symptoms.