Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (10): 2919-2920.doi: 10.4103/NRR.NRR-D-24-00679

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Brain-derived neurotrophic factor plays with TRiC: focus on synaptic dysfunction in Huntington’s disease

Yingli Gu, Kijung Sung, Chengbiao Wu*   

  1. Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
  • Online:2025-10-15 Published:2025-02-08
  • Contact: Chengbiao Wu, PhD, chw049@health.ucsd.edu.
  • Supported by:
    We thank Anna Snissarenko, Mikel Escobar, Sze Sze Chan, and other members of our laboratory from University of California San Diego, USA for their technical assistance.

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Abstract: Brain-derived neurotrophic factor (BDNF) exerts pleiotropic effects on brain processes including psychiatric disorders, aging, neurodegeneration, and metabolic homeostasis. A simple PubMed search using the key word “BDNF,” to date, yields over 33,000 publications. From fundamental biology to potential therapeutic applications, BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.