Neural Regeneration Research ›› 2025, Vol. 20 ›› Issue (11): 3213-3214.doi: 10.4103/NRR.NRR-D-24-00756

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Vagus nerve stimulation in intracerebral hemorrhage: the need for further research

Sheharyar S. Baig* , Ali N. Ali, Arshad Majid   

  1. Sheffield Institute for Translational Neuroscience, Division of Neuroscience, The University of Sheffield, Sheffield, UK
  • Online:2025-11-15 Published:2025-02-23
  • Contact: Sheharyar S. Baig, sbaig1@sheffield.ac.uk.
  • Supported by:
    SSB was supported by an Association of British Neurologists Fellowship (Stroke Association/ Berkeley Foundation). SSB, AA, and AM were supported by the NIHR Sheffield Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care (DHSC).

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Abstract: Vagus nerve stimulation (VNS) and stroke: Stroke is the second leading cause of death and the third leading cause of disability worldwide (Baig et al., 2023). There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical thrombectomy. In chronic ischemic stroke, invasive VNS paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved (Baig et al., 2023). There are no treatments of similar efficacy in acute intracerebral hemorrhage (ICH) where several promising trials, e.g., TICH-2, STOP-AUST, and TRAIGE did not show improvements in functional outcomes (Puy et al., 2023).