Abstract: Spinal cord injury (SCI) interrupts the flow of information between the brain and the spinal cord, thus leading to a loss of sensory information and motor paralysis of the body below the lesion. Surprisingly, most SCIs are incomplete and spare supraspinal pathways, especially those located within the peripheral white matter of the spinal cord, which includes reticulospinal pathways originating from the medullary reticular formation. Whereas there is abundant literature about the motor cortex, its corticospinal pathway, and its capacity to modulate functional recovery after SCI, less is known about the medullary reticular formation and its reticulospinal pathway.