Abstract: Obese individuals who subsequently sustain a traumatic brain injury (TBI) exhibit worsened outcomes including longer periods of rehabilitation (Eagle et al., 2023). In obese individuals, prolonged symptomology is associated with increased levels of circulatory pro-inflammatory markers up to 1 year postTBI (Eagle et al., 2023). Despite this, the mechanisms driving worsened outcomes remain poorly understood. Expanding our understanding of the underlying mechanisms driving obesity-induced exacerbations of TBI deficits is important at a fundamental physiological level and for the identification of novel therapeutic approaches for TBI patients with underlying metabolic dysfunction.