Neural Regeneration Research ›› 2026, Vol. 21 ›› Issue (6): 2397-2398.doi: 10.4103/NRR.NRR-D-25-00231

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Frontal synaptic plasticity: A new key to homeostatic sleep regulation

Yusuke Iino* , Shoi Shi*   

  1. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan
  • Online:2026-06-15 Published:2025-09-18
  • Contact: Yusuke Iino, MD, PhD, iino.yusuke.gf@u.tsukuba.ac.jp; Shoi Shi, PhD, shi.shoi.gf@u.tsukuba.ac.jp.
  • Supported by:
    This work was supported by Japan Society for the Promotion of Science (JSPS) Grants-in-Aid for Scientific Research (KAKENHI) (20H05894, 20H05903, 21K15136, 22K21351, 23H02518A, 23H02663, and 23K18147 to SS), JST-CREST (JPMJCR24T4 to SS), the World Premier International Research Center Initiative (WPI) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to SS (WPI-IIIS), the Top Runners in Strategy of Transborder Advanced Researches (TRiSTAR) by the MEXT to SS, and Japan Agency for Medical Research and Development (AMED) (JP21zf0127005 to SS), Cell Science Research Foundation Grant to YI, 38th Brain Science Foundation Research Grant to YI, Research Grant on Biogenic Amines and Neurological Diseases (Sumitomo pharma) to YI.

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Abstract: Sleep is a fundamental biological process essential for maintaining brain function, cognitive performance, and overall health. Despite over a century of research, the mechanisms underlying sleep homeostasis—the process by which the need for sleep accumulates during wakefulness and dissipates during sleep—remain incompletely understood. This article explores the latest advancements in sleep research, focusing on the role of synaptic plasticity in sleep homeostasis, as illuminated by Sawada et al. (2024).